Thiol peroxidase

From Proteopedia

spinqualitylabelsall models E. coli thiol peroxidase dimer complex with citric acid (PDB code 3hvs) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Thiol peroxidase or peroxiredoxin (TPX) is part of an oxidative stress defense system that uses thioredoxin and thioredoxin reductase to reduce alkyl hydroperoxides. TPX is an antioxidant which reduces peroxides and inhibits hydrogen peroxide response. TPX is also implicated in activation of transcription factors and signaling[1]. See also Bacterioferritin comigratory protein.

3D structures of thiol peroxidase

Updated on 18-December-2023

1q98 – TPX – Haemophilus influenzae
1qxh, 3hvs, 3i43, 4af2 – EcTPX – Escherichia coli
3hvv, 3hvx - EcTPX (mutant)
1xvq – TPX – Mycobacterium tuberculosis
2xpd, 2xpe, 3zrd, 3zre – YpTPX – Yersinia pseudotuberculosis
2yjh - YpTPX (mutant)
4gqc, 4gqf – TPX – Aeropyrum pernix
6udg – TPX – Elizabethkingia anophelis

References

1. ↑ Flohe L, Toppo S, Cozza G, Ursini F. A comparison of thiol peroxidase mechanisms. Antioxid Redox Signal. 2011 Aug 1;15(3):763-80. doi: 10.1089/ars.2010.3397. Epub , 2010 Nov 1. PMID:20649470 doi:http://dx.doi.org/10.1089/ars.2010.3397