Structural highlights
3zq6 is a 4 chain structure with sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.107Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
ARSA_METTH Anion-transporting ATPase. Catalyzes the extrusion of arsenite (By similarity).
Publication Abstract from PubMed
Eukaryotic tail-anchored (TA) membrane proteins are inserted into the endoplasmic reticulum by a post-translational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP*AlF(4) (-) reveals characteristic features of eukaryotic TRC40 including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized.
A conserved archaeal pathway for tail-anchored membrane protein insertion.,Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ Traffic. 2011 Jun 9. doi: 10.1111/j.1600-0854.2011.01229.x. PMID:21658170[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Sherrill J, Mariappan M, Dominik P, Hegde RS, Keenan RJ. A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic. 2011 Jun 9. doi: 10.1111/j.1600-0854.2011.01229.x. PMID:21658170 doi:10.1111/j.1600-0854.2011.01229.x
