4twk

Structural highlights

Function

KCNK2_HUMAN Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.^{[1] [2] [3]} Isoform 4: Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2 (By similarity).^{[4] [5] [6]}

See Also

• Potassium channel 3D structures

References

1. ↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
2. ↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:http://dx.doi.org/10.1007/s00424-013-1384-z
3. ↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:http://dx.doi.org/10.1038/87434
4. ↑ Meadows HJ, Benham CD, Cairns W, Gloger I, Jennings C, Medhurst AD, Murdock P, Chapman CG. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch. 2000 Apr;439(6):714-22. PMID:10784345
5. ↑ Rinne S, Renigunta V, Schlichthorl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J, Preisig-Muller R. A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels. Pflugers Arch. 2014 Aug;466(8):1559-70. doi: 10.1007/s00424-013-1384-z. Epub 2013, Nov 7. PMID:24196565 doi:http://dx.doi.org/10.1007/s00424-013-1384-z
6. ↑ Bockenhauer D, Zilberberg N, Goldstein SA. KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci. 2001 May;4(5):486-91. PMID:11319556 doi:http://dx.doi.org/10.1038/87434