8hvj

Structural highlights

Function

YICC_ECOLI Contributes to degradation of small RNA (sRNA) RhyB. Upon overexpression suppresses sRNA-mediated RhyB-silencing of multiple RNA targets but not other sRNA's targets; overexpression leads to loss of RhyB sRNA. Enables degradation of RhyB by 3' to 5' exoribonuclease PNPase (pnp) (PubMed:34210798). Endonucleolytically cleaves ssRNA, probably generating a 3'-OH and a 5'-phosphate group (PubMed:34815358).^{[1] [2]}

References

1. ↑ Chen J, To L, de Mets F, Luo X, Majdalani N, Tai CH, Gottesman S. A fluorescence-based genetic screen reveals diverse mechanisms silencing small RNA signaling in E. coli. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106964118. PMID:34210798 doi:10.1073/pnas.2106964118
2. ↑ Ingle S, Chhabra S, Chen J, Lazarus MB, Luo X, Bechhofer DH. Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis. RNA. 2022 Feb;28(2):227-238. PMID:34815358 doi:10.1261/rna.078962.121