Structural highlights
Publication Abstract from PubMed
Concanavalin A (ConA) has an intrinsic binding affinity to carbohydrates. Here, we obtained Co(2+)-Ca(2+)-ConA (2.83 A, PDB: 8I7Q) via X-ray crystallography by substituting native ConA (Mn(2+)-Ca(2+)); it has binding selectivity for high-mannose N-glycan similar to native ConA. Our findings may thus inform antiviral reagent design.
Selective interactions of Co(2+)-Ca(2+)-concanavalin A with high mannose N-glycans.,Hwang Y, Jeong JH, Lee DH, Lee SJ Dalton Trans. 2023 Dec 12. doi: 10.1039/d3dt03575a. PMID:38086668[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Hwang Y, Jeong JH, Lee DH, Lee SJ. Selective interactions of Co(2+)-Ca(2+)-concanavalin A with high mannose N-glycans. Dalton Trans. 2023 Dec 12. PMID:38086668 doi:10.1039/d3dt03575a
