1pcf

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Image:1pcf.gif

Template:STRUCTURE 1pcf

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN


Overview

The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

About this Structure

1PCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site., Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P, Nat Struct Biol. 1997 Nov;4(11):900-3. PMID:9360603 Page seeded by OCA on Sat May 3 04:56:01 2008

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