Structural highlights
Function
RS4_THET8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation.[HAMAP-Rule:MF_01306_B]
Publication Abstract from PubMed
Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA2Ile, which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG.
The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.,Voorhees RM, Mandal D, Neubauer C, Kohrer C, Rajbhandary UL, Ramakrishnan V Nat Struct Mol Biol. 2013 Mar 31. doi: 10.1038/nsmb.2545. PMID:23542153[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Voorhees RM, Mandal D, Neubauer C, Kohrer C, Rajbhandary UL, Ramakrishnan V. The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome. Nat Struct Mol Biol. 2013 Mar 31. doi: 10.1038/nsmb.2545. PMID:23542153 doi:10.1038/nsmb.2545
