8dhu

Structural highlights

Function

LARP_DROME RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:17951964, PubMed:19631203, PubMed:30772175, PubMed:35413237). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:35413237).^{[1] [2] [3] [4]}

References

1. ↑ Ichihara K, Shimizu H, Taguchi O, Yamaguchi M, Inoue YH. A Drosophila orthologue of larp protein family is required for multiple processes in male meiosis. Cell Struct Funct. 2007;32(2):89-100. PMID:17951964 doi:10.1247/csf.07027
2. ↑ Blagden SP, Gatt MK, Archambault V, Lada K, Ichihara K, Lilley KS, Inoue YH, Glover DM. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Dev Biol. 2009 Oct 1;334(1):186-97. PMID:19631203 doi:10.1016/j.ydbio.2009.07.016
3. ↑ Zhang Y, Wang ZH, Liu Y, Chen Y, Sun N, Gucek M, Zhang F, Xu H. PINK1 Inhibits Local Protein Synthesis to Limit Transmission of Deleterious Mitochondrial DNA Mutations. Mol Cell. 2019 Mar 21;73(6):1127-1137.e5. PMID:30772175 doi:10.1016/j.molcel.2019.01.013
4. ↑ Martin ET, Blatt P, Nguyen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, Fuchs G, Rangan P. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Dev Cell. 2022 Apr 11;57(7):883-900.e10. PMID:35413237 doi:10.1016/j.devcel.2022.03.005