Structural highlights
Function
NADA_THEMA Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity).
Publication Abstract from PubMed
Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.,Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clemancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S Chem Commun (Camb). 2019 Mar 11. doi: 10.1039/c8cc09023h. PMID:30855610[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clemancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S. Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination. Chem Commun (Camb). 2019 Mar 11. doi: 10.1039/c8cc09023h. PMID:30855610 doi:http://dx.doi.org/10.1039/c8cc09023h
