Structural highlights
6xtl is a 2 chain structure with sequence from Thermomonospora curvata DSM 43183. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.8Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
FGE_THECD Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile.[1] [2]
References
- ↑ Knop M, Engi P, Lemnaru R, Seebeck FP. In Vitro Reconstitution of Formylglycine-Generating Enzymes Requires Copper(I). Chembiochem. 2015 Oct 12;16(15):2147-50. doi: 10.1002/cbic.201500322. Epub 2015, Sep 25. PMID:26403223 doi:http://dx.doi.org/10.1002/cbic.201500322
- ↑ Knop M, Dang TQ, Jeschke G, Seebeck FP. Copper is a Cofactor of the Formylglycine-Generating Enzyme. Chembiochem. 2017 Jan 17;18(2):161-165. doi: 10.1002/cbic.201600359. Epub 2016, Dec 13. PMID:27862795 doi:http://dx.doi.org/10.1002/cbic.201600359
