6z4u

Structural highlights

Function

ORF9B_SARS2 Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway.^{[1] [2]}

References

1. ↑ Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell Mol Immunol. 2020 Sep;17(9):998-1000. doi: 10.1038/s41423-020-0514-8. Epub, 2020 Jul 29. PMID:32728199 doi:http://dx.doi.org/10.1038/s41423-020-0514-8
2. ↑ Brandherm L, Kobas AM, Klohn M, Bruggemann Y, Pfaender S, Rassow J, Kreimendahl S. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. Int J Mol Sci. 2021 Aug 26;22(17). pii: ijms22179233. doi: 10.3390/ijms22179233. PMID:34502139 doi:http://dx.doi.org/10.3390/ijms22179233