1rjb
From Proteopedia
|
Crystal Structure of FLT3
Contents |
Overview
FLT3 is a type III receptor tyrosine kinase that is thought to play a key, role in hematopoiesis. Certain classes of FLT3 mutations cause, constitutively activated forms of the receptor that are found in, significant numbers of patients with acute myelogenous leukemia (AML). The, mutations occur either in the activation loop, for example, as point, mutations of Asp835 or as internal tandem duplication (ITD) sequences in, the juxtamembrane (JM) domain. To further understand the nature of FLT3, autoinhibition and regulation, we have determined the crystal structure of, the autoinhibited form of FLT3. This structure shows the autoinhibitory, conformation of a complete JM domain in this class of receptor tyrosine, kinases. The detailed inhibitory mechanism of the JM domain is revealed, which is likely utilized by other members of type III receptor tyrosine, kinases.
Disease
Known diseases associated with this structure: Leukemia, acute lymphoblastic OMIM:[136351], Leukemia, acute myeloid OMIM:[136351], Leukemia, acute myeloid, reduced survival in OMIM:[136351], Melanoma, malignant sporadic OMIM:[602216], Pancreatic cancer, sporadic OMIM:[602216], Peutz-Jeghers syndrome OMIM:[602216], Testicular tumor, sporadic OMIM:[602216]
About this Structure
1RJB is a Single protein structure of sequence from Homo sapiens. Active as Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 Full crystallographic information is available from OCA.
Reference
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain., Griffith J, Black J, Faerman C, Swenson L, Wynn M, Lu F, Lippke J, Saxena K, Mol Cell. 2004 Jan 30;13(2):169-78. PMID:14759363
Page seeded by OCA on Mon Nov 12 19:04:28 2007
Categories: Homo sapiens | Single protein | Transferase | Black, J. | Faerman, C. | Griffith, J. | Lippke, J. | Lu, F. | Saxena, K. | Swenson, L. | Wynn, M. | Autoinhibition | Juxtamembrane domain | Kinase | Structure
