Structural highlights
Function
TRI58_HUMAN E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.[1]
References
- ↑ Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ. Trim58 degrades Dynein and regulates terminal erythropoiesis. Dev Cell. 2014 Sep 29;30(6):688-700. PMID:25241935 doi:10.1016/j.devcel.2014.07.021
