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Publication Abstract from PubMed

Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo- and deoxyxylo-nucleic acids (XyNA and dXyNA), containing 3' epimers of riboses and deoxyriboses, are considered as potential candidates for an orthogonal system. In this study, thermal and spectroscopic analysis show that XyNA and dXyNA form stable hairpins. The dXyNA hairpin structure determined by NMR spectroscopy contains a flexible loop that locks the stem in a stable ladder-like duplex with marginal right-handed helicity. Reduced flexibility of the dXyNA duplex observed in the stem of the hairpin demonstrates that folding of dXyNA yields more stable structures as described so far.

Stable hairpin structures formed by xylose based nucleic acids.,Mattelaer CA, Maiti M, Smets L, Maiti M, Schepers G, Mattelaer HP, Rosemeyer H, Herdewijn P, Lescrinier E Chembiochem. 2021 Jan 11. doi: 10.1002/cbic.202000803. PMID:33427360^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.