1rsf

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NMR Structure of Monomeric CAR d1 domain

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus B (CVB) and adenovirus (Ad). The normal cellular function, of CAR, which is expressed in a wide variety of tissue types, is thought, to involve homophilic cell adhesion in the developing brain. The, extracellular domain of CAR consists of two immunoglobulin (Ig) domains, termed CAR-D1 and CAR-D2. CAR-D1 is shown by sedimentation velocity to be, monomeric at pH 3.0. The solution structure and the dynamic properties of, monomeric CAR-D1 have been determined by NMR spectroscopy at pH 3.0. The, determinants of the CAR-D1 monomer-dimer equilibrium, as well as the, binding site of CVB and Ad on CAR, are discussed in light of the monomer, structure.

Disease

Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[188830], Carney complex, type 1 OMIM:[188830], Myxoma, intracardiac OMIM:[188830], Pigmented adrenocortical disease, primary, 1 OMIM:[188830], Spastic paraplegia-7 OMIM:[602783], Thyroid carcinoma, papillary OMIM:[188830]

About this Structure

1RSF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the coxsackievirus and adenovirus receptor domain 1., Jiang S, Jacobs A, Laue TM, Caffrey M, Biochemistry. 2004 Feb 24;43(7):1847-53. PMID:14967025

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