8arp

Structural highlights

Function

DBP2_YEAST ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing (PubMed:11585918, PubMed:7883168). Associates directly with chromatin, correlating with transcriptional activity (PubMed:22679025). Required for assembly of mRNA-binding proteins YRA1, NAB2, and MEX67 onto poly(A)+ RNA (PubMed:23721653).^{[1] [2] [3] [4]}

See Also

• Helicase 3D structures
• Nuclear receptor coactivator

References

1. ↑ Bond AT, Mangus DA, He F, Jacobson A. Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing. Mol Cell Biol. 2001 Nov;21(21):7366-79. PMID:11585918 doi:10.1128/MCB.21.21.7366-7379.2001
2. ↑ Cloutier SC, Ma WK, Nguyen LT, Tran EJ. The DEAD-box RNA helicase Dbp2 connects RNA quality control with repression of aberrant transcription. J Biol Chem. 2012 Jul 27;287(31):26155-66. PMID:22679025 doi:10.1074/jbc.M112.383075
3. ↑ Ma WK, Cloutier SC, Tran EJ. The DEAD-box protein Dbp2 functions with the RNA-binding protein Yra1 to promote mRNP assembly. J Mol Biol. 2013 Oct 23;425(20):3824-38. PMID:23721653 doi:10.1016/j.jmb.2013.05.016
4. ↑ He F, Jacobson A. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev. 1995 Feb 15;9(4):437-54. PMID:7883168 doi:10.1101/gad.9.4.437