3jc8

Structural highlights

Function

PILB_MYXXD ATPase component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers. Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (PubMed:28779124, PubMed:26965631). PilB ATPase activity is also essential for T4P extension while antagonist PilT ATPase activity is required for T4P retraction (PubMed:18223089). In addition, functions as a regulator of exopolysaccharide (EPS) downstream of the T4P filament and upstream of the Dif signaling (PubMed:28779124).^{[1] [2] [3]}

References

1. ↑ Jakovljevic V, Leonardy S, Hoppert M, Søgaard-Andersen L. PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus. J Bacteriol. 2008 Apr;190(7):2411-21. PMID:18223089 doi:10.1128/JB.01793-07
2. ↑ Chang YW, Rettberg LA, Treuner-Lange A, Iwasa J, Sogaard-Andersen L, Jensen GJ. Architecture of the type IVa pilus machine. Science. 2016 Mar 11;351(6278):aad2001. doi: 10.1126/science.aad2001. Epub 2016, Mar 10. PMID:26965631 doi:http://dx.doi.org/10.1126/science.aad2001
3. ↑ Black WP, Wang L, Jing X, Saldaña RC, Li F, Scharf BE, Schubot FD, Yang Z. The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus. Sci Rep. 2017 Aug 4;7(1):7263. PMID:28779124 doi:10.1038/s41598-017-07594-x