1ky8

Structural highlights

Function

GAPN_THETE Catalyzes the irreversible NAD(P)-dependent non-phosphorylating oxidation of glyceraldehyde-3-phosphate (GAP) to 3-phosphoglycerate (3PG). It is highly specific for D-GAP.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Aldehyde dehydrogenase 3D structures
• Glyceraldehyde-3-phosphate dehydrogenase 3D structures

References

1. ↑ Hensel R, Laumann S, Lang J, Heumann H, Lottspeich F. Characterization of two D-glyceraldehyde-3-phosphate dehydrogenases from the extremely thermophilic archaebacterium Thermoproteus tenax. Eur J Biochem. 1987 Dec 30;170(1-2):325-33. PMID:3121324
2. ↑ Brunner NA, Brinkmann H, Siebers B, Hensel R. NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. J Biol Chem. 1998 Mar 13;273(11):6149-56. PMID:9497334