1r3f

Structural highlights

Function

TRUB_ECOLI Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Guide-independent Pseudouridine synthase
• Pseudouridine synthase 3D structures

References

1. ↑ Nurse K, Wrzesinski J, Bakin A, Lane BG, Ofengand J. Purification, cloning, and properties of the tRNA psi 55 synthase from Escherichia coli. RNA. 1995 Mar;1(1):102-12. PMID:7489483
2. ↑ Gutgsell N, Englund N, Niu L, Kaya Y, Lane BG, Ofengand J. Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. RNA. 2000 Dec;6(12):1870-81. PMID:11142385