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1sac
From Proteopedia
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THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
Contents |
Overview
The three-dimensional structure of pentameric human serum amyloid P, component at high resolution, the first reported for a pentraxin, reveals, that the tertiary fold is remarkably similar to that of the legume, lectins. Carboxylate and phosphate compounds bind directly to two calcium, ions; interactions with a carboxyethylidene ring are mediated by Asn 59, and Gln 148 ligands of the calcium ions. These X-ray results indicate the, probable modes of binding of the biologically important ligands, DNA and, amyloid fibrils.
Disease
Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]
About this Structure
1SAC is a Single protein structure of sequence from Homo sapiens with CA and ACY as ligands. Full crystallographic information is available from OCA.
Reference
Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934
Page seeded by OCA on Mon Nov 12 19:11:43 2007
Categories: Homo sapiens | Single protein | Blundell, T.L. | Emsley, J. | Hara, B.P.O. | Oliva, G. | Pepys, M.B. | Srinivasan, N. | Tickle, I.J. | White, H.E. | Wood, S.P. | ACY | CA | Amyloid protein
