Structural highlights
Function
SP2SA_BACSU Toxic component of a toxin-antitoxin (TA) module. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.[1]
References
- ↑ Adler E, Barak I, Stragier P. Bacillus subtilis locus encoding a killer protein and its antidote. J Bacteriol. 2001 Jun;183(12):3574-81. PMID:11371520 doi:10.1128/JB.183.12.3574-3581.2001
