Tyrosine phosphatase 3D structures

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3D Structures of tyrosine phosphatase

Updated on 15-February-2024 - For a general description of the protein see Tyrosine phosphatase {{#tree:id=OrganizedByTopic|openlevels=0|

• Class I

• Non-receptor type tyrosine phosphatase; Domains – catalytic 1-321;

• • 8u1e - hPTP-1b catalytic domain - human
    
  • 1a5y, 2hnp, 2hnq, 1oem, 1oeo, 1oes, 1oet, 1oeu, 1oev, 1sug, 2cm2, 2cm3, 3eu0, 3i80, [[3a5j, 6ntp, 6xe8, 6xee, 7key, 7l0c, 7lfo, 7rin - hPTP-1b catalytic domain
    
  • 1gfy, 1i57, 1pa1, 2f6f, 3a5k, 3zv2, 3qkp, 6olq, 6olv, 6omy, 6pfw, 6pg0, 6pgt, 6pha, 6phs, 6cwv, 6cwu, 7fre, 7frs, 7frt, 7fru, 7gsc, 7gtw, 7gtx, 7gty, 7gtz, 7gu0, 7gu1, 7gu2, 7gu3, 7gu4, 7gu5, 7gu6, 7gu7, 7gu8, 7gu9, 7gua, 7gub, 7guc, 7ken, 7mkz, 7mn9, 7mnc, 7mou, 7mov, 7s4f, 8du7, 8exi, 8xoy - hPTP-1b catalytic domain (mutant)
  • 3lnx - hPTP-1e PDZ2 domain 1361-1456
    
  • 3pdz, 7qcx - hPTP-1e PDZ2 domain – NMR
    
  • 2m0z - hPTP-1e PDZ2 domain (mutant) – NMR
    
  • 5k9v – hPTPN1 catalytic domain
    
  • 4qah, 4qap, 4qbe, 4qbw, 5kaa, 5ka8, 5ka4, 5ka2, 5ka1, 5ka0 – hPTPN1 catalytic domain (mutant)
    
  • 6zz4, 7f5n, 7f5o – hPTPN2 catalytic domain
    
  • 2b49 – hPTPN3 catalytic domain
    
  • 4qun – hPTPN3 catalytic domain (mutant)
    
  • 2i75 – hPTPN4 611-926
    
  • 2cs5 – hPTPN4 PDZ domain 507-612 – NMR
    
  • 2vph - hPTPN4 PDZ domain
    
  • 2bij, 8sls, 8slt, 8slu – hPTPN5 catalytic domain 258-561
    
  • 2bv5 - hPTPN5 catalytic domain (mutant)
    
  • 1zco, 2a3k – hPTPN7 65-358
    
  • 2gp0, 2hvl, 2qdc, 2qdm, 2qdp, 3o4s, 3o4t, 3o4u – hPTPN7 65-360 (mutant)
    
  • 2pa5 – hPTPN9 catalytic domain 277-582
    
  • 5hde - hPTPN12 catalytic domain 1-301
    
  • 5glj - hPTPN13 PDZ1 domain 1086-1178
    
  • 1wch - hPTPN13 2163-2477
    
  • 2bzl – hPTPN14 catalytic domain 886-1187
    
  • 2oc3 – hPTPN18 catalytic domain 6-299
    
  • 8gvl – hPTPN21 FERM domain 18-318
    
  • 8gvv – hPTPN21 PTP domain 876-1174 (mutant)
    
  • 8gxe – hPTPN21 FERM+PTP domains
    
  • 2p6x, 2qcj, 3h2x – hPTPN22 catalytic domain 1-302
    
  • 5cru, 5mjz, 3rau – hRPTP23 domain Bro residues 1-361
    
  • 5lm2 – hRPTP23 residues 362-713
    
  • 1rxd, 1xm2 – hPTP PRL-1
    
  • 1r6h, 1v3a, 2mbc – hPTP PRL-3 – NMR
    
  • 1bvh - bPTP – bovine – NMR
    
  • 1c0e – bPTP (mutant) – bovine
    
  • 1zck, 1x24 – rPTP 4A1 – rat
    
  • 3i36 – rPTP- catalytic domain
    
  • 1gm1 - mPTP-BL PDZ2 domain – mouse – NMR
    
  • 1ozi - mPTP-BL PDZ2 domain (mutant) – NMR
    
  • 3rgo – mPTP-1
    
  • 3rgq – mPTP-1 + Pi(5)P
    
  • 2yz1 – mPTP SHPS-1 catalytic domain
    
  • 6x39 – mPTP F FN#5 domain
    
  • 6gbd – mPTP-13 SH3 domain - NMR
    
  • 2pi7 – cPTP CRYP-2 catalytic domain – chicken
    
  • 7mod, 7moi, 7moj, 7mok, 7mol, 7mom – AtPTP DSP1 49-215 – Arabidopsis thaliana
    
  • 6krw, 6krx – AtPTP1 1-340
    
  • 1d1p, 2j16 – yPTP – yeast
    
  • 2j17 - yPTP (mutant)
    
  • 5xw4 – yPTPN CDC14
    
  • 6e3b – yPTPN SIW14 catalytic domain
    
  • 1g4w – StPTP – Salmonella typhimurium
    
  • 2i6i, 3ro1 – SsPTP – Sulfolobus solfataricus
    
  • 2z72, 1v73, 2zbm – PTP residues 22-361 – Shewanella
    
  • 3js5, 3jvi – EhPTP – Entamoeba histolytica
    
  • 2wjd, 2wje, 2wjf – PTP – Streptococcus pneumonia
    
  • 3qy6, 3qy7, 3qy8 – BsPTP – Bacillus subtilis
    
  • 4d74 – PTP AMSI 1-144 (mutant) – Erwinia amylovora
    
  • 8dhi, 8dhj – PTP 1-246 (mutant) – Clostridioides difficile
    

• Non-receptor type PTP complex with peptide

• • 1ptt, 1ptu, 1g1f, 1g1g, 1g1h, 1een, 1eeo, 8exj, 8exk, 8exm, 8exn, 8eya, 8eyb, 8eyc, 8f88 - hPTP-1b catalytic domain (mutant) + peptide
    
  • 3i7z - hPTP-b catalytic domain + peptide
    
  • 7qcy - hPTP-1e PDZ2 domain + peptide – NMR
    

3zmp, 3zmq, 4zrt – hPTPN1 catalytic domain + peptide

• • 4qum, 4rh5, 4rh9, 4rhg, 4s0g – hPTPN3 catalytic domain (mutant) 628-909 + peptide
    
  • 6hks, 6t36, 8cqy, 8oep – hPTPN3 PDZ domain 489-597 + peptide
    
  • 3nfk, 3nfl, 5eyz, 5ez0 - hPTPN4 PDZ domain + peptide
    
  • 7vze - hPTPN4 PDZ domain + papillomavirus peptide
    
  • 3d42, 3d44 – hPTPN7 catalytic domain (mutant) + peptide
    
  • [[4icz, 6kzq, 6l03 – hPTPN9 catalytic domain + peptide
    
  • 5o2p – hPTPN12 SH3 domain/peptide
    
  • 3lny, 7xty - hPTPN13 PDZ2 domain 1362-1456 + peptide
    
  • 4gfu, 4gfv - hPTPN18 residues 6-300 + peptide
    
  • 4nnd - hPTPN18 residues 6-300 (mutant) + ERBB-2
    
  • 3brh, 3olr - hPTPN22 catalytic domain + peptide
    
  • 3omh - hPTPN22 catalytic domain (mutant) + peptide
    
  • 5crv, 5mk3, 5mk2, 5mk1, 5mk0, 5mjy – hRPTP23 domain Bro + peptide
    
  • 5lm1 – hRPTP23 residues 362-713 + UBAP-1 peptide
    
  • 3rz2 - rPTP 4A1 + peptide
    
  • 1aya, 1ayb, 1ayc, 1ayd – mPTP Syp N terminal SH2 domain + peptide
    
  • 1vj6 – mPTP-BL PDZ2 domain + APC C terminal – NMR
    
  • 6gbe – mPTPN13 PDZ3 domain + PRK2 peptide – NMR
    
  • 5xw5 – yPTPN CDC14 + SWI6 peptide
    
  • 6g86 – yPTPN CDC14 + SIC1 peptide
    
  • 6g85, 6g84 – yPTPN CDC14 + CBK1 peptide
    
  • 2dxp, 2i6o – SsPTP (mutant) + peptide
    

• Non-receptor type PTP complex with small molecule

• • 1ptv, 1pty - hPTP-1b catalytic domain (mutant) + phosphotyrosine
    
  • 1aax - hPTP-1b catalytic domain (mutant) + bis-phosphophenyl methane
    
  • 1ecv, 1c83, 1c84, 1c85, 1c86, 1c87, 1c88, 1g7f, 1g7g, 1jf7, 1l8g, 1kak, 1kav, 1lqf, 1nl9, 1nny, 1no6, 1nz7, 1ony, 1onz, 1ph0, 1pxh, 1pyn, 1q1m, 1q6j, 1q6m, 1q6n, 1q6p, 1q6s, 1q6t, 1qxk, 1t48, 1t49, 1t4j, 1xbo, 1wax, 2bgd, 2bge, 2azr, 2b07, 2f6t, 2f6v, 2f6w, 2f6y, 2f6z, 2f70, 2f71, 2fjn, 2cm7, 2cm8, 2cma, 2cmb, 2cmc, 2h4g, 2h4k, 2hb1, 2cne, 2cnf, 2cng, 2cnh, 2cni, 2nt7, 2nta, 2veu, 2vev, 2vew, 2vex, 2vey, 2qbp, 2qbq, 2qbr, 2qbs, 3cwe, 3d9c, 2zmm, 2zn7, 3eax, 3eb1, 3sme, 4i8n, 4y14, 5t19, 5k9w, 6w30, 7gs7, 7gsa, 7gsb, 7gsl, 7gsm, 7gso, 7gsr, 7gst, 7gsv, 7gsw, 7gsy, 7gt0, [[[7gt1]], [7gt3]], 7gt4, 7gt5, 7gt6, 7gt7, 7gt9, 7gta, 7gtd, 7gte, 7gtg, 7gth, 7gti, 7gtk, 7gtl, 7gtm, 7gtn, 7gto, 7gtt, 7gtu, 7klx, 7mm1, 8g6a, 8g65, 8g67, 8g68, 8g69, 8skl - hPTP-1b catalytic domain 1-298 + inhibitor
    
  • 1nwl, 1nwe, 2fjm, 5ka3, 5ka7, 5ka9, 5kab, 5kac, 5kad, 5qde, 5qdf, 5qdg, 5qdh, 5qdi, 5qdj, 5qdk, 5qdl, 5qdm, 5qdn, 5qdo, 5qdp, 5qdq, 5qdr, 5qds, 5qdt, 5qdu, 5qdv, 5qdw, 5qdx, 5qdy, 5qdz, 5qe0, 5qe1, 5qe2, 5qe3, 5qe4, 5qe5, 5qe6, 5qe7, 5qe8, 5qe9, 5qea, 5qeb, 5qec, 5qed, 5qee, 5qef, 5qeg, 5qeh, 5qei, 5qej, 5qek, 5qel, 5qem, 5qen, 5qeo, 5qep, 5qeq, 5qer, 5qes, 5qet, 5qeu, 5qev, 5qew, 5qex, 5qey, 5qez, 5qf0, 5qf1, 5qf2, 5qf3, 5qf4, 5qf5, 5qf6, 5qf7, 5qf8, 5qf9, 5qfa, 5qfb, 5qfc, 5qfd, 5qfe, 5qff, 5qfg, [[5qfih], 5qfi, 5qfj, 5qfk, 5qfl, 5qfm, 5qfn, 5qfo, 5qfp, 5qfq, 5qfr, 5qfs, 5qft, 5qfu, 5qfv, 5qfw, 5qfx, 5qfy, 5qfz, 5qg0, 5qg1, 5qg2, 5qg3, 5qg4, 5qg5, 5qg6, 5qg7, 5qg8, 5qg9, 5qga, 5qgb, 5qgc, 5qgd, 5qge, 5qgf, 7fqm, 7fqn, 7fqo, 7fqp, 7fqq, 7fqr, 7fqs, 7fqu, 7fqv, 7fqw, 7fqx, 7fqy, 7fqz, 7frg, 7frh, 7fri, 7frj, 7frk, 7frl, 7frm, 7frn, 7fro, 7frp, 7frq, 7frr, 7gs9, 7gsd, 7gse, 7gsf, 7gsg, 7gsh, 7gsi, 7gsj, 7gsk, 7gsn, 7gsq, 7gsu, 7gsx, 7gsz, 7gt8, 7gtb, 7gtc, 7gtf, 7gtj, 7gtp, 7gtq, 7gtr, 7gts, 7gtv, 7mn7, 7mna, 7mnb, 7mnd, 7mne, 7mnf, 7mow - hPTP-1b catalytic domain (mutant) + inhibitor
    
  • 4bjo – hPTP1 catalytic domain + NO3
    
  • 6xed, 6xeg – hPTPN1b + WO4
    
  • 6xea – hPTPN1b + VO4
    
  • 6pm8, 6xef, 7l0h – hPTPN1b (mutant) + VO4
    
  • 7uad – hPTPN2 1-314 + inhibitor
    
  • 4ri4, 4ri5 – hPTPN3 catalytic domain (mutant) + VO4
    
  • 2cjz - hPTPN5 catalytic domain 258-563 (mutant) + phosphotyrosine
    
  • 5ow1, 5ovx, 5ovr – hPTP5 catalytic domain + inhibitor
    
  • 4ge2, 4ge5, 4ge6 – hPTP9 catalytic domain + inhibitor
    
  • 2m10 - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR
    
  • 2qct, 4j51 – hPTPN22 catalytic domain + inhibitor
    
  • 5bx1 – hPTP PRL-1 + inhibitor
    
  • 1dg9 – bPTP + HEPES
    
  • 1zcl - rPTP 4A1 (mutant) + sulfate
    
  • 7moe, 7mof, 7mog, 7moh – AtPTP DSP1 + inhibitor
    
  • 1d2a – yPTP + adenine
    
  • 1d1q – yPTP (mutant) + PNPP
    
  • 2i6p - SsPTP (mutant) + PNPP
    
  • 2i6j – SsPTP + phosphate
    
  • 2i6m – SsPTP + WO4
    
  • 3ido – EhPTP + HEPES
    
  • 7mpd – SsoPTP + inhibitor – Ssccharolobus solfataricus
    
  • 7mpc – SsoPTP + VO4
    
  • 7ezn – PTP + VO4 – Cryptococcus neoformans
    

• Non-receptor type PTP complex with protein

• • 2b4s - hPTP-b catalytic domain + insulin receptor
    
  • 2gph - hPTPN7 catalytic domain (mutant) + MAPK2
    
  • 6iwd – hPTPN14 886-1187 + HPV18 CR3 domain
    
  • 5k25, 5k24, 5k23 – hPTP PRL-2 + CNNM3
    
  • 5k22 – hPTP PRL-2 (mutant) + CNNM3
    
  • 5tsr – hPTP PRL-3 (mutant) + CNNM3
    
  • 6nmv, 6nmu, 6nmt, 6nms, 6nmr, 6bit - hPTP SHPS-1 + antibody
    
  • 5lxq – mPTP PRL-1 + CNNM2
    
  • 6wus – mPTP PRL-1 (mutant) + CNNM2
    
  • 5mmz – mPTP 4A1 + CNNM2
    
  • 4pbv, 4pbw – cPTP CRYP-alpha1 29-316 + TrkC
    
  • 4zj7 – yPTPN CDC14 C terminal + importin
    
  • 1g4u – StPTP + RAS-related C3 botulinum toxin substrate
    
  • 1jyo – StPTP + secretion chaperone SICP
    

• Non-receptor type PTP SHP-1 or tyrosine-protein phosphatase non-receptor type 6

• • 3ps5 – hPTP SHP-1 (mutant)
    
  • 1gwz, 2b3o, 4hjp – hPTP SHP-1 catalytic domain 242-528
    
  • 4gry, 4grz, 4hjq – hPTP SHP-1 catalytic domain (mutant)
    
  • 1x6c - hPTP SHP-1 C-terminal SH2 domain 105-220 – NMR
    
  • 2dju, 2edy – hPTP SHP-1 FN #3 domain 309-401 NMR
    
  • 2dn7 – hPTP SHP-1 FN3 #6 domain 811-904 - NMR
    
  • 1fpr, 4gs0 - hPTP SHP-1 catalytic domain + peptide
    
  • 2rmx, 2yu7 – hPTP SHP-1 C-terminal SH2 domain + peptide – NMR
    
  • 6sm5 - hPTP SHP-1 C-terminal SH2 domain + monobody
    

• Non-receptor type PTP SHP-2 or tyrosine-protein phosphatase non-receptor type 11

• • 4dgp – hPTP SHP-2 SH2+catalytic domains 1-532
    
  • 2shp, 4dgx, 4gwf, 4h1o, 4h34, 4nwf, 4nwg, 4ohd, 4ohe, 4ohh, 4ohi, 4ohl, 5bk8, 6ihz, 6crf, 6cmp – hPTP SHP-2 SH2+catalytic domains (mutant)
    
  • 6cmq - hPTP SHP-2 106-529
    
  • 3b7o, 3zm0, 3zm1, 3zm2, 3zm3 – hPTP SHP-2 catalytic domain 248-527
    
  • 5j8r, 5i6v, 5ibm, 5ibs, 7emn – hPTP SHP-2 catalytic domain (mutant)
    
  • 3tl0, 3tkz, 4qsy, 5df6, 5x7b, 5x94 – hPTPN11 SH2 domain 1-220 + peptide
    
  • 6roy - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide
    
  • 6roz - hPTP SHP-2 N- terminal SH2 domain + ITSM peptide
    
  • 6r5g - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR
    
  • 7ppl, 7ppm, 7ppn - hPTP SHP-2 catalytic domain (mutant) + peptide
    
  • 3mow - hPTP SHP-2 catalytic domain + inhibitor
    
  • 3o5x, 4pvg, 4rdd, 5ehp, 5ehr, 5xzr, 6md7, 6md9, 6mda, 6mdb, 6mdc, 6mdd, 6wu8, 7jvm, 7jvn, 7r75, 7r7d, 7r7i, 7r7l, 7rct, 7vxg, 8b5y, 8cbh, 8t6d, 8u7w, 8u7x - hPTP SHP-2 SH2+catalytic domains + inhibitor
    
  • 6cmr, 6cms, 6crg - hPTP SHP-2 SH2+catalytic domains (mutant) + inhibitor
    
  • 8t7q - hPTP SHP-2 SH2+catalytic domains + drug
    
  • 4je4, 4jeg – hPTP SHP-2 N-terminal SH2 domain + monobody
    
  • 7tvj – hPTP SHP-2 catalytic domain 224-525 + monobody
    

• Yersinia PTP Yop

• • 1yts, 4yaa, 4z6b, 4zi4, 4zn5, 6xft - YePTP catalytic domain (mutant) – Yersinia enterocolitica
    
  • 7l0i – YePTP (mutant)
    
  • 1xxp, 1xxv - YePTP catalytic domain (mutant) + peptide
    
  • 2i42, 7l0m – YePTP (mutant) + VO4
    
  • 1ypt, 1ytw – YePTP catalytic domain + WO4
    
  • 1ytn - YePTP catalytic domain + NO3
    
  • 1lyv - YePTP catalytic domain (mutant) + phosphate
    
  • 1pa9, 3bm8 - YePTP catalytic domain (mutant) + inhibitor
    
  • 3u96 - YePTP catalytic domain (mutant) + PNCS
    
  • 1huf – YpPTP - Yersinia pestis
    
  • 1qz0 - YpPTP catalytic domain + peptide
    
  • 2y2f - YpPTP catalytic domain + inhibitor
    
  • 1k46 - YpPTP N terminal domain
    
  • 1m0v - YpPTP N terminal domain + peptide – NMR
    
  • 4gf3 – YpPTP + Yop targeting protein
    

• Receptor-type PTP

• • 1yfo, 2i1y – mRPTP-α catalytic domain
    
  • 1p15 - mRPTP-α D2 domain
    
  • 3pxh - mRPTP Ig domains
    
  • 1jln, 2a8b - mRPTP-R catalytic domain
    
  • 3sr9 - mRPTP-σ residues 1326 – 1901
    
  • 2nv5 – rRPRP
    
  • 2yd4 - cRPTP-σ Ig1-2 domain – chicken
    
  • 2yd1, 2yd2, 3pxj – DmRPTP Ig1-2 domain – Drosophila melanogaster
    
  • 3s3e – DmRPTP-10D catalytic domain
    
  • 6x38 – DmRPTP FN5 domain
    

• Human receptor-type PTP

• • 6uzt - hRPTP-α catalytic domain
    
  • 2ahs – hRPTP-β
    
  • 2i3r, 2i5x - hRPTP-β catalytic domain
    
  • 2hc1, 2hc2 - hRPTP-β catalytic domain (mutant)
    
  • 2h4v, 2pbn, 3qcb – hRPTP-γ domain 1
    
  • 3qcn - hRPTP-γ domain 1 (mutant)
    
  • 2nlk - hRPTP-γ catalytic domain
    
  • 3jxh - hRPTP-γ CA-like domain
    
  • 5fmv - hRPTP-γ domain D1-D4
    
  • 5fn6 - hRPTP-γ domain D1-D3
    
  • 5fn7 - hRPTP-γ domain D1-D2
    
  • 5fn8 - rRPTP-γ domain D3-D4
    
  • 4yfe - hRPTP-δ FN1-FN2 domain 321-511
    
  • 4yfg - hRPTP-δ Ig1-FN1 domain 21-501
    
  • 2dlh, 1x5z - hRPTP-δ FN3 domain 405-514 – NMR
    
  • 2yd6, 2yd7 - hRPTP-δ Ig1-2 domain 21-220
    
  • 6x3a - hRPTP-δ FN4-FN6 domain 607-916
    
  • 2jjd - hRPTP-ε residues 107-697
    
  • 6d4d - hRPTP-ε domain D1 residues 22-313
    
  • 6d4f, 6d3f - hRPTP-ε domain D2 residues 425-700
    
  • 8a1f - hRPTP-kappa N-terminal residues 28-385
    
  • 2c7s - hRPTP-kappa residues 865-1154
    
  • 1rpm - hRPTP-μ catalytic domain
    
  • 2c9a - hRPTP-μ MAM-IG module
    
  • 2v5y - hRPTP-μ extracellular region
    
  • 8a16, 8a17 - hRPTP- FN#3-4 domain 478-723
    
  • 2g59, 2gjt - hRPTP- catalytic domain
    
  • 7u08 - hRPTP-eta residues 37-374
    
  • 7u01 - hRPTP-eta residues 206-364
    
  • 2cfv – hRPTP-eta residues 1019-1311
    
  • 2nz6 - hRPTP-eta residues 1019-1311 (mutant)
    
  • 2dle - hRPTP-eta FN3 domain – NMR
    
  • 2qep – hRPTP-ν2 D1 domain
    
  • 4hti, 4htj – hRPTP-ν2 membrane proximal ectodomain
    
  • 2ooq – hRPTP-ρ
    
  • 2fh7, 4bpc - hRPTP-σ catalytic domain (mutant)
    
  • 2yd9 - hRPTP-σ Ig1-3 domain (mutant)
    
  • 2yd3, 2yd5 - hRPTP-σ Ig1-2 domain
    
  • 4pbx - hRPTP-σ residues 30-588
    
  • 3jxf - hRPTP-ζ CA-like domain
    
  • 5awx - hRPTP-ζ D1 domain
    
  • 2qt7, 3n01, 3n4w, 3ng8, 3np5 – hRPTP IA-2
    
  • 6tpv - hRPTP-F 1st-2nd FN3 domain 319-512
    
  • 6tpu, 6tpt - hRPTP-F 3rd-4th FN3 domain 513-705
    
  • 4n5u - hRPTP-F 4th FN3 domain 601-705
    
  • 2edx - hRPTP-F 4th FN3 domain – NMR
    
  • 6tpw - hRPTP-F 1st-4th FN3 domain
    
  • 6j6u - rRPTP-ζ D1-D2 domain
    
  • 3jxg, 3jxh - mRPTP-γ CA-like domain
    
  • 7xc0 - hRPTP-H 797-1086
    

• Receptor-type PTP complexes

• • 2h02, 2h04, 2i3u, 2i4e, 2i4g, 2i4h - hRPTP-β catalytic domain + inhibitor
    
  • 2h03 - hRPTP-β catalytic domain (mutant) + inhibitor
    
  • 2hy3, 3qcc, 3qcd - hRPTP-γ domain 1 + VO4
    
  • 3qce, 3qcf, 3qcg, 3qch, 3qci, 3qcj, 3qck - hRPTP-γ domain 1 + inhibitor
    
  • 3qcl, 3qcm - hRPTP-γ domain 1 (mutant) + inhibitor
    
  • 5e5r - hRPTP-γ domain CA + contactin 3
    
  • 4rca, 4y61 - hRPTP-δ Ig1-Ig2 domain 21-318 + SLITRK1
    
  • 5xnp - hRPTP-δ Ig1-Ig2 domain (mutant) + SALM5
    
  • 6kip - hRPTP-δ residues 1617-1912 + liprin
    
  • 5y32, 4yfd, 4yh7, 5wy8 - hRPTP-δ Ig1-Ig2 domain + IL1RAPL1
    
  • 5xnp - hRPTP-d Ig1-Ig2 domain (mutant) + SALM5
    
  • 6kip - hRPTP-d residues 1617-1912 + liprin
    
  • 2yd8 - hRPTP-σ Ig1-2 domain + sucrose octasulfate
    
  • 3s97 - hRPTP-zeta CA-like domain 34-302 + congtactin Ig domains
    
  • 8fn8, 8fn9 – hPTP zeta FN domain 310-411 + tenascin fg domain
    
  • 5h08 – hPTP zeta D1 domain 1698-1993 + inhibitor
    
  • 6kr4 - hRPTP-F residues 1332-1907 + liprin
    
  • 1ygr – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide
    
  • 5e5u - mRPTP-γ domain CA + contactin 6
    
  • 3kld - mRPTP-γ CA-like domain + contactin 4
    
  • 5xwu - mRPTP- Ig1-Ig3 domain + LRR-IG
    
  • 5xwt - mRPTP- Ig1-FN1 domain + LRR-IG
    
  • 3s3f - DmRPTP-10D catalytic domain + VO4
    
  • 3s3h - DmRPTP-10D catalytic domain + peptide
    
  • 3s3k - DmRPTP-10D catalytic domain + inhibitor
    

• Dual-specificity PTP DUSP see Map kinase phosphatase

• Class II – Low molecular weight PTP (LMW-PTP)

• • 1xww, 4z99, 5jnr, 5jns, 5jnt – hLMW-PTP
    
  • 6y2v, 6y2w – hLMW-PTP (mutant)
    
  • 1phr – bLMW-PTP
    
  • 5jnv – bLMW-PTP (mutant)
    
  • 5jnu – mLMW-PTP
    
  • 7cuy – DmLMW-PTP
    
  • 1p8a – LMW-PTP (mutant) – Tritrichomonas foetus – NMR
    
  • 2cwd – LMW-PTP – Thermus thermophilus
    
  • 5got – LMW-PTP – Streptococcus pyogenes
    
  • 1u2p, 2luo – MtLMW-PTP – Mycobacterium tuberculosis
    
  • 2fek, 2wja – LMW-PTP Wzb – Escherichia coli
    
  • 4eti, 4etm, 4kk3 – BsLMW-PTP
    
  • 4etn, 4kk4 – BsLMW-PTP (mutant)
    
  • 7dhd – VvLMW-PTP Wzb – Vibrio vulnificus
    
  • 4egs – LMW-PTP N-terminal 1-146 – Thermoanaerobacter tengcongensis
    
  • 2gi4 – LMW-PTP – Campylobacter jejuni
    

• LMW-PTP complex

• • 3n8i, 5kqg, 5kql, 5kqm, 5kqp, 7kh8, 7uw6 – hLMW-PTP + inhibitor
    
  • 4z9a – hLMW-PTP + phenylmethanesulfonic acid
    
  • 4z9b – hLMW-PTP + benzylphosphonic acid
    
  • 1z12 - bLMW-PTP + VO4
    
  • 1z13 - bPTP + MoO4
    
  • 5jnw – bLMW-PTP + inhibitor
    
  • 3rof – LMW-PTP-A + peptide – Staphylococcus aureus
    
  • 1u2q – MtLMW-PTP + glycerol
    
  • 2oz5 – MtLMW-PTP + inhibitor
    
  • 7dhe, 7dhf – VvLMW-PTP Wzb + inhibitor
    

• For LMW-PTP from Synechocystis see Arsenate reductase

• Class III – CDC25 or M-phase inducer phosphatase 2

• • 1c25 – hCDC25A catalytic domain (mutant)
    
  • 1qb0, 1cwr, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq - hCDC25B catalytic domain
    
  • 2a2k, 2ifd, 2ifv - hCDC25B catalytic domain (mutant)
    
  • 4wh7 - hCDC25B catalytic domain (mutant) + ligand
    
  • 4wh9 - hCDC25B catalytic domain (mutant) + inhibitor
    
  • 1cwr, 1cws - hCDC25B catalytic domain + WO4
    
  • 1cwt - hCDC25B catalytic domain + Methyl-Hg
    
  • 3op3 – hCDC25C residues 270-462

• Class IV

• • 4tvv – PTP – Legionella pneumophila
    

• T-cell tyrosine phosphatase

• • 1l8k – hTC-PTP

• Other tyrosine phosphatases

• • 4az1 – PTP – Trypanosoma cruzi
    
  • 4r0s – PaPTP – Pseudomonas aeruginosa
    
  • 4r0t – PaPTP (mutant) + tyrosine
    
  • 5ncr – PTP (mutant) – ORF virus
    

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