3ix1

Structural highlights

Function

THIY_HALH5 Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products. Binds the formylaminopyrimidine N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Does not bind thiamine.^{[1] [2]}

References

1. ↑ Jenkins AH, Schyns G, Potot S, Sun G, Begley TP. A new thiamin salvage pathway. Nat Chem Biol. 2007 Aug;3(8):492-7. Epub 2007 Jul 8. PMID:17618314 doi:http://dx.doi.org/10.1038/nchembio.2007.13
2. ↑ Bale S, Rajashankar KR, Perry K, Begley TP, Ealick SE. HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues . Biochemistry. 2010 Oct 19;49(41):8929-36. PMID:20873853 doi:10.1021/bi101209t