3sk1

Structural highlights

Function

EHPR_ENTAG Required for resistance to the phenazine antibiotic D-alanylgriseoluteic acid (AGA), an antibiotic produced by E.agglomerans itself, and thus protects the bacterium against phenazine toxicity. Probably binds AGA and acts as a chaperone that works in tandem with a membrane transporter for subsequent antibiotic secretion.^{[1] [2]}

References

1. ↑ Giddens SR, Feng Y, Mahanty HK. Characterization of a novel phenazine antibiotic gene cluster in Erwinia herbicola Eh1087. Mol Microbiol. 2002 Aug;45(3):769-83. PMID:12139622 doi:10.1046/j.1365-2958.2002.03048.x
2. ↑ Yu S, Vit A, Devenish S, Mahanty HK, Itzen A, Goody RS, Blankenfeldt W. Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin / mitomycin C resistance in other bacteria. BMC Struct Biol. 2011 Aug 17;11(1):33. PMID:21849072 doi:10.1186/1472-6807-11-33