3tgn

Structural highlights

Function

ADCR_STRP2 Zinc-responsive regulator that acts both as a repressor and as an activator by regulating directly the promoters of its target genes. In the presence of zinc, directly represses the expression of the adcRCBA operon, of genes coding for a group of surface antigen zinc-binding pneumococcal histidine triad proteins (PhtA, PhtB, PhtD and PhtE), and of adcAII. Can also activate expression of adh.^{[1] [2]}

References

1. ↑ Reyes-Caballero H, Guerra AJ, Jacobsen FE, Kazmierczak KM, Cowart D, Koppolu UM, Scott RA, Winkler ME, Giedroc DP. The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor. J Mol Biol. 2010 Oct 22;403(2):197-216. doi: 10.1016/j.jmb.2010.08.030. Epub 2010, Sep 8. PMID:20804771 doi:http://dx.doi.org/10.1016/j.jmb.2010.08.030
2. ↑ Shafeeq S, Kloosterman TG, Kuipers OP. Transcriptional response of Streptococcus pneumoniae to Zn2+) limitation and the repressor/activator function of AdcR. Metallomics. 2011 Jun;3(6):609-18. doi: 10.1039/c1mt00030f. Epub 2011 May 21. PMID:21603707 doi:http://dx.doi.org/10.1039/c1mt00030f