4f3v

Structural highlights

Function

ECCA1_MYCTU Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates.^{[1] [2]}

References

1. ↑ Luthra A, Mahmood A, Arora A, Ramachandran R. Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis. J Biol Chem. 2008 Dec 26;283(52):36532-41. doi: 10.1074/jbc.M807144200. Epub 2008, Oct 30. PMID:18974091 doi:10.1074/jbc.M807144200
2. ↑ Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun. 2006 Jan;74(1):88-98. PMID:16368961 doi:10.1128/IAI.74.1.88-98.2006