1srs

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Image:1srs.gif

1srs, resolution 3.200Å

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SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA

Contents

Overview

The human serum response factor is a transcription factor belonging to the, MADS domain protein family with members characterized from the plant and, animal kingdoms. The X-ray crystal structure of the serum response factor, core in a specific-recognition DNA complex shows that the functions of DNA, binding, dimerization and accessory-factor interaction are compactly, integrated into a novel protein unit. The intrinsic and induced, conformation of the serum response element DNA is the principal DNA, feature recognized in the specific complex.

Disease

Known disease associated with this structure: Osteoarthritis of hip, female-specific, susceptibility to OMIM:[605083]

About this Structure

1SRS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of serum response factor core bound to DNA., Pellegrini L, Tan S, Richmond TJ, Nature. 1995 Aug 10;376(6540):490-8. PMID:7637780

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