Structural highlights
Function
ILVC_MYCTU Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. It is also able to use 3-hydroxypyruvate (HP).[1]
See Also
References
- ↑ Lv Y, Kandale A, Wun SJ, McGeary RP, Williams SJ, Kobe B, Sieber V, Schembri MA, Schenk G, Guddat LW. Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 A resolution: A potential target for anti-tuberculosis drug discovery. FEBS J. 2016 Feb 15. doi: 10.1111/febs.13672. PMID:26876563 doi:http://dx.doi.org/10.1111/febs.13672
