Structural highlights
7t88 is a 1 chain structure with sequence from Escherichia coli str. K-12 substr. MG1655. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.1Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
PTA_ECOLI Involved in acetate metabolism (PubMed:16080684). Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate (PubMed:16080684). The direction of the overall reaction changes depending on growth conditions (PubMed:16080684). On minimal medium acetyl-CoA is generated. In rich medium acetyl-CoA is converted to acetate and allowing the cell to dump the excess of acetylation potential in exchange for energy in the form of ATP (PubMed:15687190). The main pathway for acetate production during exponential phase (PubMed:16080684).[1] [2]
References
- ↑ Shi IY, Stansbury J, Kuzminov A. A defect in the acetyl coenzyme A<-->acetate pathway poisons recombinational repair-deficient mutants of Escherichia coli. J Bacteriol. 2005 Feb;187(4):1266-75. PMID:15687190 doi:10.1128/JB.187.4.1266-1275.2005
- ↑ Dittrich CR, Bennett GN, San KY. Characterization of the acetate-producing pathways in Escherichia coli. Biotechnol Prog. 2005 Jul-Aug;21(4):1062-7. PMID:16080684 doi:10.1021/bp050073s
