1svc

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Image:1svc.gif

1svc, resolution 2.600Å

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NFKB P50 HOMODIMER BOUND TO DNA

Overview

The structure of a large fragment of the p50 subunit of the human, transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that, the Rel-homology region has two beta-barrel domains that grip DNA in the, major groove. Both domains contact the DNA backbone. The amino-terminal, specificity domain contains a recognition loop that interacts with DNA, bases; the carboxy-terminal dimerization domain bears the site of I-kappa, B interaction. The folds of these domains are related to, immunoglobulin-like modules. The amino-terminal domain also resembles the, core domain of p53.

About this Structure

1SVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the NF-kappa B p50 homodimer bound to DNA., Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC, Nature. 1995 Jan 26;373(6512):311-7. PMID:7830764

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