Structural highlights
Function
YCJR_ECOLI Catalyzes the epimerization at C4 of 3-dehydro-D-gulosides leading to 3-dehydro-D-glucosides. Probably functions in a metabolic pathway that transforms D-gulosides to D-glucosides. Can use methyl alpha-3-dehydro-D-glucoside and methyl beta-3-dehydro-D-glucoside as substrates in vitro. However, the actual specific physiological substrates for this metabolic pathway are unknown. Cannot act on D-psicose, D-fructose, D-tagatose, D-sorbose, L-xylulose, or L-ribulose.[1]
References
- ↑ Mukherjee K, Huddleston JP, Narindoshvili T, Nemmara VV, Raushel FM. Functional Characterization of the ycjQRS Gene Cluster from Escherichia coli: A Novel Pathway for the Transformation of d-Gulosides to d-Glucosides. Biochemistry. 2019 Mar 12;58(10):1388-1399. PMID:30742415 doi:10.1021/acs.biochem.8b01278
