| Structural highlights
Function
SEPT8_HUMAN Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).[UniProtKB:B0BNF1][1] Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.[2]
References
- ↑ Blaser S, Horn J, Wurmell P, Bauer H, Strumpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Thromb Haemost. 2004 May;91(5):959-66. doi: 10.1160/TH03-09-0578. PMID:15116257 doi:http://dx.doi.org/10.1160/TH03-09-0578
- ↑ Kurkinen KM, Marttinen M, Turner L, Natunen T, Makinen P, Haapalinna F, Sarajarvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M. SEPT8 modulates beta-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr, 15. PMID:27084579 doi:http://dx.doi.org/10.1242/jcs.185215
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