Structural highlights
Function
ORC2_DROME Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.[1]
References
- ↑ Loupart ML, Krause SA, Heck MS. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants. Curr Biol. 2000 Dec 14-28;10(24):1547-56. PMID:11137005
