Structural highlights
Function
GEN_HUMAN Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.[1]
References
- ↑ Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC. Identification of Holliday junction resolvases from humans and yeast. Nature. 2008 Nov 20;456(7220):357-61. doi: 10.1038/nature07470. PMID:19020614 doi:http://dx.doi.org/10.1038/nature07470
