Structural highlights
Function
PILA_PSEAE Major component of the type IV pilus (T4P) that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility facilitated by cycles of extension, adhesion, and retraction of T4P fibers (PubMed:9282737, PubMed:26041805, PubMed:31431558). In addition, plays a critical role in type II secretion of exoenzymes by interacting with specific components such as XcpT or XcpU (PubMed:9282737). Modulates host calcium signaling through interaction with host calcium-modulating cyclophilin ligand (PubMed:23266901).[1] [2] [3] [4]
References
- ↑ Okuda J, Hayashi N, Arakawa M, Minagawa S, Gotoh N. Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand. J Infect Chemother. 2013 Aug;19(4):653-64. PMID:23266901 doi:10.1007/s10156-012-0536-y
- ↑ Persat A, Inclan YF, Engel JN, Stone HA, Gitai Z. Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7563-8. PMID:26041805 doi:10.1073/pnas.1502025112
- ↑ Nieto V, Kroken AR, Grosser MR, Smith BE, Metruccio MME, Hagan P, Hallsten ME, Evans DJ, Fleiszig SMJ. Type IV Pili Can Mediate Bacterial Motility within Epithelial Cells. mBio. 2019 Aug 20;10(4):e02880-18. PMID:31431558 doi:10.1128/mBio.02880-18
- ↑ Lu HM, Motley ST, Lory S. Interactions of the components of the general secretion pathway: role of Pseudomonas aeruginosa type IV pilin subunits in complex formation and extracellular protein secretion. Mol Microbiol. 1997 Jul;25(2):247-59. PMID:9282737 doi:10.1046/j.1365-2958.1997.4561818.x
