3a2p

Structural highlights

Function

NYLA_FLASK Specifically catalyzes the hydrolysis of 6-aminohexanoic acid cyclic dimer (1,8-diazacyclotetradecane-2,9-dione) to form the linear dimer 6-aminohexanoyl-6-aminohexanoic acid. Is inactive on 6-aminohexanoic acid oligomers (degree of polymerization 2 to 6), various other cyclic amides, cyclic diamides, linear amides, oligopeptides, and casein. Allows the bacterium to grow on a medium containing 6-aminohexanoic acid cyclic dimer as the sole carbon and nitrogen sources.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• 6-aminohexanoate-dimer hydrolase 3D structures

References

1. ↑ Kinoshita S, Negoro S, Muramatsu M, Bisaria VS, Sawada S, Okada H. 6-Aminohexanoic acid cyclic dimer hydrolase. A new cyclic amide hydrolase produced by Achromobacter guttatus KI74. Eur J Biochem. 1977 Nov 1;80(2):489-95. PMID:923591