4ggo

Structural highlights

Function

FABV_TREDE Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of the carbon-carbon double bond of crotonyl-CoA to yield butyryl-CoA. In vitro it can also use hexenoyl-CoA and dodecenoyl-CoA as substrates (PubMed:22906002).^{[1] [2] [3]}

References

1. ↑ Tucci S, Martin W. A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola. FEBS Lett. 2007 Apr 17;581(8):1561-6. doi: 10.1016/j.febslet.2007.03.013. Epub, 2007 Mar 15. PMID:17382934 doi:http://dx.doi.org/10.1016/j.febslet.2007.03.013
2. ↑ Bond-Watts BB, Weeks AM, Chang MC. Biochemical and Structural Characterization of the trans-Enoyl-CoA Reductase from Treponema denticola. Biochemistry. 2012 Aug 20. PMID:22906002 doi:10.1021/bi300879n
3. ↑ Hu K, Zhao M, Zhang T, Zha M, Zhong C, Jiang Y, Ding J. Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutulicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism. Biochem J. 2012 Oct 11. PMID:23050861 doi:10.1042/BJ20120871