Structural highlights
Function
ESXO_MYCTU Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages.[1]
References
- ↑ Mohanty S, Dal Molin M, Ganguli G, Padhi A, Jena P, Selchow P, Sengupta S, Meuli M, Sander P, Sonawane A. Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages. Tuberculosis (Edinb). 2016 Jan;96:44-57. doi: 10.1016/j.tube.2015.11.006. Epub, 2015 Nov 24. PMID:26786654 doi:http://dx.doi.org/10.1016/j.tube.2015.11.006
