Structural highlights
Function
ZC12A_HUMAN Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.[1] [2] [3]
See Also
References
- ↑ Zhou L, Azfer A, Niu J, Graham S, Choudhury M, Adamski FM, Younce C, Binkley PF, Kolattukudy PE. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ Res. 2006 May 12;98(9):1177-85. Epub 2006 Mar 30. PMID:16574901 doi:http://dx.doi.org/10.1161/01.RES.0000220106.64661.71
- ↑ Niu J, Azfer A, Zhelyabovska O, Fatma S, Kolattukudy PE. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem. 2008 May 23;283(21):14542-51. doi: 10.1074/jbc.M802139200. Epub 2008, Mar 24. PMID:18364357 doi:http://dx.doi.org/10.1074/jbc.M802139200
- ↑ Xu J, Peng W, Sun Y, Wang X, Xu Y, Li X, Gao G, Rao Z. Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase. Nucleic Acids Res. 2012 May 4. PMID:22561375 doi:10.1093/nar/gks359
