4e2q

Structural highlights

Function

UGHY_ARATH Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.^{[1] [2] [3]}

References

1. ↑ Werner AK, Romeis T, Witte CP. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat Chem Biol. 2010 Jan;6(1):19-21. Epub 2009 Nov 22. PMID:19935661 doi:http://dx.doi.org/nchembio.265
2. ↑ Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem Biol. 2010 Feb 19;5(2):203-14. doi: 10.1021/cb900248n. PMID:20038185 doi:http://dx.doi.org/10.1021/cb900248n
3. ↑ Shin I, Percudani R, Rhee S. Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. J Biol Chem. 2012 May 25;287(22):18796-805. Epub 2012 Apr 5. PMID:22493446 doi:10.1074/jbc.M111.331819