5jci

Structural highlights

Function

MDAR3_ORYSJ Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process. Ascorbate is a major antioxidant against reactive oxygen species (ROS) and nitric oxide (NO) (PubMed:24376554, PubMed:27652777). Can use NADPH as electron donor, but possesses lower activity compared to NADH as electron donor (PubMed:27652777).^{[1] [2]}

References

1. ↑ Wang X, Hargrove MS. Nitric oxide in plants: the roles of ascorbate and hemoglobin. PLoS One. 2013 Dec 20;8(12):e82611. PMID:24376554 doi:10.1371/journal.pone.0082611
2. ↑ Park AK, Kim IS, Do H, Jeon BW, Lee CW, Roh SJ, Shin SC, Park H, Kim YS, Kim YH, Yoon HS, Lee JH, Kim HW. Structure and catalytic mechanism of monodehydroascorbate reductase, MDHAR, from Oryza sativa L. japonica. Sci Rep. 2016 Sep 22;6:33903. doi: 10.1038/srep33903. PMID:27652777 doi:http://dx.doi.org/10.1038/srep33903