1tnr
From Proteopedia
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CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX: IMPLICATIONS FOR TNF RECEPTOR ACTIVATION
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Overview
The X-ray crystal structure of the complex of the extracellular domain of, the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta, has been determined at 2.85 A resolution. The complex has three receptor, molecules bound symmetrically to one TNF beta trimer. The receptor, fragment, a very elongated end to end assembly of four similar folding, domains, binds in the groove between two adjacent TNF beta subunits. The, structure of the complex defines the orientation of the ligand with, respect to the cell membrane and provides a model for TNF receptor, activation. The novel fold of the TNF receptor structure is likely to be, representative of the nerve growth factor (NGF)/TNF receptor family as a, whole.
Disease
Known diseases associated with this structure: Myocardial infarction, susceptibility to OMIM:[153440], Osteopetrosis, autosomal recessive 2 OMIM:[602642], Periodic fever, familial OMIM:[191190]
About this Structure
1TNR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation., Banner DW, D'Arcy A, Janes W, Gentz R, Schoenfeld HJ, Broger C, Loetscher H, Lesslauer W, Cell. 1993 May 7;73(3):431-45. PMID:8387891
Page seeded by OCA on Mon Nov 12 19:26:19 2007
