Introduction
Proline Peptidase Overview
History
discovery and whatnot
Function
town tartness
Structure
[1]
Overview
Catalytic Triad
[1]
Mechanism
The picture of the mechanism is inserted but not visible, maybe too high of a quality?
Once a substrate is bound in the active site, DPPIV utilizes a covalent catalysis (MAKE LINK) mechanism to cleave the substrate at the penultimate position. Asp708 of the catalytic triad (MAKE SCENE) (Ser630, His 740, Asp708) pulls electron density from His740 allowing the histidine to pull electron density from Ser630, making serine a stronger nucleophile. The water molecule attacks the carbonyl carbon, breaking the newly formed covalent bo9nd, and releasing the first two residues of the starting substrate. The active site resets.
Figure 5. Mechanism of the catalytic triad of DPPIV.
Inhibitors
Relevance
Diabetes
HIV/AIDS
