Introduction
Figure 1: Main Structure of the Glucose Depending Insulinotropic Receptor (GIP-R).
GIP-R is a receptor that binds glucose within many different cells.
Function
The GIP receptor helps facilitate movement of glucose within a cell. [1].
Tirzepatide
Tirzepatide has been used as a treatment for Type 2 diabetes. It has 39 total residues in the structure.
Disease
Diabetes is very bad for you[2].
Relevance
Structural highlights
Active Site
References
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
Student Contributors
SaraKathryn Kalkhoff
Camille Gaudet
