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Structural highlights

Function

DCSB_STRLA Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the hydrolysis of N(omega)-hydroxy-L-arginine (NHA) to yield hydroxyurea (HU) and L-ornithine.^{[1] [2]}

References

1. ↑ Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob Agents Chemother. 2010 Mar;54(3):1132-9. doi: 10.1128/AAC.01226-09., Epub 2010 Jan 19. PMID:20086163 doi:http://dx.doi.org/10.1128/AAC.01226-09
2. ↑ Kumagai T, Takagi K, Koyama Y, Matoba Y, Oda K, Noda M, Sugiyama M. Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine. Antimicrob Agents Chemother. 2012 Jul;56(7):3682-9. doi: 10.1128/AAC.00614-12., Epub 2012 Apr 30. PMID:22547619 doi:http://dx.doi.org/10.1128/AAC.00614-12