6a9v

Structural highlights

Function

ICP55_YEAST Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.^{[1] [2]}

References

1. ↑ Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O. Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem. 2009 Oct 30;284(44):30200-8. Epub 2009 Aug 31. PMID:19720832 doi:http://dx.doi.org/M109.034694
2. ↑ Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C. Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell. 2009 Oct 16;139(2):428-39. PMID:19837041 doi:http://dx.doi.org/S0092-8674(09)01032-0