Structural highlights
Function
SELO_ECOLI Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). Cannot use GTP, CTP or UTP as cosubstrate. AMPylates SucA at 'Thr-405' and GrxA on 'Tyr-13'. Regulates protein S-glutathionylation levels probably by AMPylation of deglutathionylation enzymes such as GrxA. Probably involved in redox homeostasis.[1]
References
- ↑ Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbanska M, Lobocka M, Grishin NV, Orth K, Kucharczyk R, Pawlowski K, Tomchick DR, Tagliabracci VS. Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell. 2018 Sep 25. pii: S0092-8674(18)31107-3. doi: 10.1016/j.cell.2018.08.046. PMID:30270044 doi:http://dx.doi.org/10.1016/j.cell.2018.08.046
