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1ttg
From Proteopedia
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THE THREE-DIMENSIONAL STRUCTURE OF THE TENTH TYPE III MODULE OF FIBRONECTIN: AN INSIGHT INTO RGD-MEDIATED INTERACTIONS
Contents |
Overview
The solution structure of the tenth type III module of fibronectin has, been determined using nuclear magnetic resonance techniques. The molecule, has a fold similar to that of immunoglobulin domains, with seven beta, strands forming two antiparallel beta sheets, which pack against each, other. Both beta sheets contribute conserved hydrophobic residues to a, compact core. The topology is more similar to that of domain 2 of CD4, PapD, and the extracellular domain of the human growth hormone receptor, than to that of immunoglobulin C domains. The module contains an, Arg-Gly-Asp sequence known to be involved in cell adhesion. This, tripeptide is solvent exposed and lies on a conformationally mobile loop, between strands F and G, consistent with its cell adhesion function.
Disease
Known diseases associated with this structure: Ehlers-Danlos syndrome, type X, 225310 (1) OMIM:[135600]
About this Structure
1TTG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions., Main AL, Harvey TS, Baron M, Boyd J, Campbell ID, Cell. 1992 Nov 13;71(4):671-8. PMID:1423622
Page seeded by OCA on Mon Nov 12 19:27:52 2007
