Structural highlights
Function
CD3E_MOUSE The CD3 complex mediates signal transduction.CD3G_MOUSE Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G (PubMed:25920998).[UniProtKB:P09693][1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Lauritsen JP, Boding L, Buus TB, Kongsbak M, Levring TB, Rode AK, Bonefeld CM, Geisler C. Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif. Int Immunol. 2015 Aug;27(8):393-404. PMID:25920998 doi:10.1093/intimm/dxv022
- ↑ Haks MC, Krimpenfort P, Borst J, Kruisbeek AM. The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages. EMBO J. 1998 Apr 1;17(7):1871-82. PMID:9524111 doi:10.1093/emboj/17.7.1871
