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Structural highlights

Function

PORTL_LAMBD Forms the portal vertex of the capsid (PubMed:6228056, PubMed:6232391). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (Probable). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (PubMed:6232391). Binds to the terminase subunits to form the packaging machine (PubMed:7799432).[HAMAP-Rule:MF_04135]^{[1] [2] [3]}

References

1. ↑ Kochan J, Murialdo H. Early intermediates in bacteriophage lambda prohead assembly. II. Identification of biologically active intermediates. Virology. 1983 Nov;131(1):100-15. PMID:6228056 doi:10.1016/0042-6822(83)90537-8
2. ↑ Kochan J, Carrascosa JL, Murialdo H. Bacteriophage lambda preconnectors. Purification and structure. J Mol Biol. 1984 Apr 15;174(3):433-47. PMID:6232391 doi:10.1016/0022-2836(84)90330-9
3. ↑ Yeo A, Feiss M. Specific interaction of terminase, the DNA packaging enzyme of bacteriophage lambda, with the portal protein of the prohead. J Mol Biol. 1995 Jan 13;245(2):141-50. PMID:7799432 doi:10.1006/jmbi.1994.0013